From Infogalactic: the planetary knowledge core. the science of changing the genetic features of animals and plants. Genetic heterogeneity is a phenomenon in which a single phenotype or genetic disorder may be caused by any one of a multiple number of alleles or non-allele mutations. Other articles where Genetic heterogeneity is discussed: human genetic disease: Autosomal dominant inheritance: …the same clinical disorder (genetic heterogeneity). The disorder results from any one of thousands of different mutations in any one of multiple different genes, but all the implicated genes encode proteins in related pathways ( Turnpenny and Ellard, Emery's Elements of Medical Genetics, 13th Edition. cal adj. Previous and recent studies favor the clinical and, Although the association between HLA genes and SLE has been widely evaluated, the results are not often reproducible, and most studies are limited by small sample sizes and, Both autosomal dominant inheritance and autosomal recessive inheritance of nanophthalmos have been reported, and a fair amount of, They discuss general principles of evolution and ecology as they apply to cancer, the molecular mechanisms that underlie, Cerebrovascular Events Secondary to Pulmonary Arteriovenous Malformation Based on.
Genetic heterogeneity describes genetic variation from the normal population.

b. heterogeneity definition: 1. the fact of consisting of parts or things that are very different from each other: 2. the fact…. If the children are red-haired, one of their parents must have a gene for red hair. For example, retinitis pigmentosa has autosomal dominant, autosomal recessive, and X-linked origins. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. A genome sequence is the complete list of the nucleotides (A, C, G, and T for DNA genomes) that make up all the chromosomes of an individual or a species. Keywords: Alzheimer’s disease, Genetic, Heterogeneity, Presenilin, Amyloid precursor protein, Apolipoprotein E Introduction Alzheimer’s disease (AD) is often conceptualized as a unitary clinicopathological entity characterized by progressive loss of memory and other changes in cognition and behavior that ultimately affect self-care. any of the basic elements of heredity, passed from parents to their offspring. For example, there are over 1000 known mutant alleles of the CFTR gene that cause cystic fibrosis. [1] This is in contrast to pleiotropy, where a single gene may cause multiple phenotypic expressions or disorders.

In medicine and genetics, a genetic or allelic heterogeneous condition is one where the same disease or condition can be caused, or contributed to, by several factors, or … Clinically, genetic heterogeneity refers to diseases that result from multiple gene abnormalities. Genetic Heterogeneity is responsible for the presence of many medical disorders in humans. Multiple alleles are involved in this disease.[5]. Achondroplasia is characterized by allelic homogeneity, such that essentially all affected individuals carry exactly the same mutation. By signing up for this email, you are agreeing to news, offers, and information from Encyclopaedia Britannica. Multiple gene abnormalities are seen in disorders such as autism, cystic fibrosis, and retinitis pigmentosa. [4] Heritable diseases are a result of a genotype that varies from the population standard. …in the affected population (allelic heterogeneity). [4] In relation to diseases, one gene mutation (varying from population) can cause a phenotypic disorder. Allelic heterogeneity means that different mutations within a single gene locus (forming multiple alleles of that gene) cause the same phenotypic expression. …the same clinical disorder (genetic heterogeneity). Of or relating to genetics or genes. Locus heterogeneity means that variations in completely unrelated gene loci cause a single disorder. 2.

human genetic disease: Autosomal dominant inheritance. In some cases even mutations in different genes can lead to the same clinical disorder (genetic heterogeneity). An inherited predisposition for the development of breast cancer has been investigated.