Hot my labs and my levels are at 2000. The validity of routinely recorded smoking status in UK primary care: a cross-sectional study, Indications for cobalamin level assessment in departments of internal medicine: a prospective practice survey, Impact of the introduction of guidelines on vitamin B12 testing, Analysing survival data from clinical trials and observational studies, Regression modeling strategies: with applications to linear models, logistic and ordinal regression, and survival analysis, Effects of folic acid supplementation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals, Random measurement error and regression dilution bias, Macrophage serum markers in pneumococcal bacteremia: prediction of survival by soluble CD163, Elevated plasma vitamin B12 levels and cancer prognosis: a population-based cohort study, Elevated plasma vitamin B12 levels and risk of venous thromboembolism among cancer patients: a population-based cohort study, Utilizing SEER Registries for Cancer Survivor Studies, Predicted Gene Expression Interaction with NSAIDs on CRC, Telomere Maintenance Variants and Colorectal Cancer Survival, Cancer Epidemiology, Biomarkers & Prevention, Disclosure of Potential Conflicts of Interest.

We found the strongest association between high plasma B12 and risk of cancers of the upper gastrointestinal tract, the liver, the pancreas, the lung, and myeloid malignancies. Both came back at 1800. The IRRs for specific cancers are shown in Table 3. Their characteristics are shown in Supplementary Table S5. & detox juicing guide. The sponsors of this study had no role in the initiation, planning, design, or conduct of the study, data acquisition, management and analyses, interpretation of results, writing and approval of the manuscript, or the decision to submit the manuscript for publication. Hence, we might have included persons with high plasma B12 levels due to use of over-the-counter high-dose B12 drugs in the high B12 groups.

According to a review published in the Journal of Psychopharmacology, oral doses of 800 micrograms of folic acid and one milligram of vitamin B12 daily may help improve treatment outcomes for depression. What Are the Benefits of High-Potency Vitamin D3? NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. I have since had two other B12 levels drawn, 6 months ago and last week. Cancer Epidemiology, Biomarkers & Prevention Our results showed that high B12 levels are a marker of occult, not yet diagnosed cancer, also in the UK population and in the primary care setting. Models were adjusted for sex, age, Townsend quintile, smoking, alcohol use, and BMI. If a B12 blood test indicates your levels are excessive, it may be the sign of a disease.

I don't have the MTHFR gene, which I've been tested, and my other labs are normal. Vitamin B12 can also cause very rare but serious allergic reactions. Smokers had higher one-year CIPs risk than nonsmokers (CIP for persons with plasma B12 >1,000 pmol/L, smoker vs. nonsmoker: 6.79 [4.90–9.08] vs. 5.54 [4.55–6.67]). 1. Healthline: What Are the Side Effects of Vitamin B-12? I do not take supplements but am concerned about the High B-12 results. A surprising number of medications can deplete the body of vitamin B12. Covariates included sex, age, Townsend quintile score, body mass index (WHO definition: body mass index [BMI]: <18.5, 18.5–24.9, 25–29.9, and ≥30 kg/m2), smoking status (never, former, and current), and alcohol use (non-drinker, former drinker, moderate drinker [within UK guidelines, alcohol units per week: male: ≤21/female: ≤14], and heavy drinker [consuming more than UK guidelines; alcohol units per week: male: 22–49/female: 15–35], and very heavy drinker [alcohol units per week: male: ≥50/female: >35]). Milk and milk products such as yogurt and cheese are also sources of vitamin B12. Ultimately, we cannot assess the indication for measuring plasma B12 for the individual person, but our results in the cohort of first-time statin users were robust. Once you have that base level, document it and try to avoid anything adverse.